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PubMed research supports that insulin resistance is a core factor in various health issues beyond diabetes, including fatty liver, cognitive impairment, and cardiovascular disease (Springer)

If you respond well to appetite suppression as a mechanism, that response is likely to be amplified with GLP-1 medications

Pioglitazone has lower PPAR agonism compared with rosiglitazone but has more profound effects on MASH, potentially mediated by the mitochondrial target of thiazolidinediones, specifically the mitochondrial pyruvate carrier

PMCID: PMC7942234 ) Cogen AL, Desai K, Elder D, Rosenbach M (2019) Acute photodistributed exanthematous pustulosis associated with liraglutide treatment